CA9 (carbonic anhydrase 9) is a transmembrane protein and one of only two known tumor associated carbonic anhydrase isoenzymes. Carbonic anhydrase (CA) is a large class of zinc metalloenzymes that catalyze the reversible hydration reaction of carbon dioxide. They participate in various biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. Their related pathways include cellular responses to stimuli and the self degradation of E3 ubiquitin ligase COP1, an important homolog of which is CA14.
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