TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains) is a Protein Coding gene. Diseases associated with TIGIT include Endocervical Carcinoma and Chromophobe Renal Cell Carcinoma. Among its related pathways are Interactions of natural killer cells in pancreatic cancer and Hematopoietic Stem Cells and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is CD226.Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
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