CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) is a Protein Coding gene. Diseases associated with CTLA4 include Immune Dysregulation With Autoimmunity, Immunodeficiency, And Lymphoproliferation and Celiac Disease 3. Among its related pathways are Gene expression (Transcription) and CD28 co-stimulation. An important paralog of this gene is CD28.Inhibitory receptor acting as a major negative regulator of T-cell responses.The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
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